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Hotels in Middlesboro    Below is only a selection of Middlesboro Hotels. Search them all with the search box on the right. Best Western Inn - Middlesboro 1623 E Cumberland Avenue Middlesboro, KY 40965-1224 Information Come and enjoy southern hospitality with the Best Western Inn, conveniently located in Historical Do More Check Rates Holiday Inn Express MIDDLESBORO - Middlesboro 1252 N 12TH STREET Middlesboro, KY 40965 Information The Holiday Inn Express Middlesboro Hotel is located in Middlesboro's blend of historic woodlands, More Check Rates

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